Enediyne antibiotic chromoprotein

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WebJan 17, 2014 · One of the isolated strains (HB3267) kills insects and is resistant to the majority of the antibiotics used in laboratories and hospitals, including aminoglycosides, ß-lactams, cationic peptides, chromoprotein enediyne antibiotics, dihydrofolate reductase inhibitors, fluoroquinolones and quinolones, glycopeptide antibiotics, macrolides ... WebSep 1, 2009 · C-1027 is a chromoprotein antitumor antibiotic whose enediyne chromophore consists of an enediyne core, a deoxy aminosugar, a benzoxazolinate, and a beta-amino acid moiety.

In vivo characterization of NcsB3 to establish the complete ...

WebChromoprotein enediynes are characterized by an unstable chromophore enediyne bound to an apoprotein. The chromophore is unreactive when bound to the apoprotein. Upon its release, it reacts to form 1,4-didehydrobenzene and … WebLike most of the 9-membered enediynes, C-1027 is a chromoprotein antibiotic consisting of an enediyne chromophore and an apo-protein. 1 Since its biosynthetic gene cluster was cloned from Streptomyces globisporus in 2002, 4, 5 C-1027 biosynthesis has been extensively studied, 6-8 and the unique enediyne core structure was proposed to be … robert young fort smith ar

Enediyne - an overview ScienceDirect Topics

WebMay 11, 2011 · The protein associated with kedarcidin and zinostatin (and possibly all of the chromoprotein enediyne antibiotics) not only stabilizes the enediyne chromophore but also has been shown to selectively proteolyze basic peptides and proteins, such as … Glycosides present another diverse class of secondary metabolites, where a sugar … Polyketide-nonribosomal peptides can further be structurally diversified by … Zhen Xi, Irving H. Goldberg, in Comprehensive Natural Products … WebApr 25, 2003 · The C-1027 enediyne antibiotic contains an unusual 3-chloro-4,5-dihydroxy-β-phenylalanine moiety that is thought to be derived from tyrosine by an aminomutase reaction. However, none of the genes identified within the C-1027 gene cluster encode proteins with strong homology to known aminomutases. The sgcC4 gene encodes a … Webmembered enediyne compound produced by S. carzinosta-ticus, is the most studied among the chromoprotein type enediyne antibiotics. It consists of a 1:1 complex of a nonpeptide chromophore (NCS chromophore) and a pep-tide apoprotein (Apo-NCS). The NCS chromophore con-sists of three different moieties: a nine-membered enediyne robert young funeral home

Recent advances in the synthetic studies of nine-membered enediyne …

Biosynthesis of the β-Amino Acid Moiety of the Enediyne …

WebOct 13, 2009 · The small molecule component of chromoprotein enediyne antitumor antibiotics is biosynthesized through a convergent route, incorporating amino acid, polyketide, and carbohydrate building blocks around a central enediyne hydrocarbon core. The naphthoic acid moiety of the enediyne neocarzinostatin plays key roles in the … WebRong-guang Shao, Yong-su Zhen, in Recent Advances in Cancer Research and Therapy, 2012. 7.2.3 mAb–Enediyne Drugs. The enediyne antitumor antibiotics with highly … robert young friartonWebJun 16, 2010 · Similar to most of the nine-membered enediynes, C-1027 is a chromoprotein antibiotic consisting of an enediyne chromophore and an apoprotein. 1 As its biosynthetic gene cluster was cloned from ... robert young flowers matlock

"WebSep 1, 2016 · The chromoprotein family of enediyne antitumor antibiotics includes some of the most cytotoxic natural products known to date.13, 14 As exemplified by C-1027,15, 16, 17, 18 the chromoprotein is a noncovalent protein-small molecule complex consisting of an apo-protein (CagA) and an enediyne chromophore (C-1027) (Fig. 1). " - Enediyne antibiotic chromoprotein

Enediyne antibiotic chromoprotein

Method of treatment for glioblastoma by administering a VEGF …

WebAug 16, 2002 · The enediynes exemplify nature's ingenuity. We have cloned and characterized the biosynthetic locus coding for perhaps the most notorious member of … WebThe invention provides methods and compositions to detect expression of one or more biomarkers for identifying and treating patients having glioblastomas who are likely to be responsive to VEGF antagonist therapy. The invention also provides kits and articles of manufacture for use in the methods.

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WebThis invention concerns methods of treating a patient diagnosed with glioblastoma comprising administering to said patient a therapy comprising an effective amount of an anti-VEGF antibody and a chemotherapeutic. WebOct 26, 2009 · The molecule of lidamycin that belongs to the chromoprotein family of antitumor antibiotics is composed of an apoprotein (LDP) and an enediyne …

WebC-1027 is an extremely potent antitumor agent that causes double-stranded DNA cleavages. It is a unique small molecule−protein complex composed of a highly reactive enediyne … WebAbstract: The recent discovery of nine-membered cyclic enediyne chromophores (1 for the antitumor antibiotics (2-1027; 2 for kedarcidin) stabilized by specific apoproteins …

WebC-1027, also called lidamycin, is a chromoprotein antitu-mor antibiotic produced by Streptomyces globisporus C-1027 [1]. As a member of the enediyne family character- ... an apoprotein and a 9 ... WebSep 1, 1993 · Kedarcidin is a potent antitumor antibiotic chromoprotein, composed of an enediyne-containing chromophore embedded in a highly acidic single chain polypeptide. The chromophore was shown to cleave duplex DNA site-specifically in a single-stranded manner. Herein, we report that in vitro, the kedarcidin apoprotein, which lacks any …

WebThe enediyne antitumor antibiotic C-1027 chromoprotein is produced by Streptomyces globisporus. The biosynthesis of the (S)-3-chloro-4,5-dihydroxy-β-phenylalanine moiety …

WebThe enediyne antitumor antibiotic C-1027 chromoprotein is produced by Streptomyces globisporus. The biosynthesis of the (S)-3-chloro-4,5-dihydroxy-β-phenylalanine moiety … robert young florists matlock derbyshireWebA structurally novel class of antitumor natural products called enediyne antibiotics including calicheamicin, esperamicin, dynemicin A, neocardinostatin, kedarcidin, C-1027, maduropeptin, and nazmenamicin is attracting a great deal of attention due to their remarkable mode of action and unusual structures [1, 2]. ... Chromoprotein; Download ... robert young full moviesWebNational Center for Biotechnology Information robert young footballWebMay 1, 2008 · Abstract. Dynemicin is a novel anthraquinone-fused member of the 10-membered enediyne antitumor antibiotic family. The development of a genetic system for the dynemicin producer Micromonospora chersina confirmed, for the first time, the requirement of the putative enediyne core biosynthetic genes (dynE8, U14 and U15) … robert young glasgowWebKedarcidin is a chromoprotein antitumor antibiotic first isolated from an Actinomycete in 1992, comprising an ansa-bridged enediyne chromophore (shown) as well as an apoprotein that serves to stabilize the toxin in the Actinomycete. Like other members of the enediyne class of drugs—so named for the nine-or-ten-membered core structure bearing an … robert young ghost movieWebC-1027 is a chromoprotein enediyne antitumor antibiotic, consisting of the CagA apoprotein and the C-1027 chromophore. The C-1027 chromophore features a nine-membered enediyne core appended with three peripheral moieties, including an (S)-3-chloro-5-hydroxy-β-tyrosine. In a convergent biosynthesis of the C-1027 chromophore, … robert young free moviesWebThis invention describes a method of conjugating a cell binding agent such as an antibody with an effector group (e.g., a cytotoxic agent) or a reporter group (e.g., a radionuclide), whereby the reporter or effector group is first reacted with a bifunctional linker and the mixture is then used without purification for the conjugation reaction with the cell binding … robert young goodwin