WebTake this medication by mouth with or without food as directed by your doctor, usually once daily in the morning. If you have stomach upset, you may take this medication with or after a meal or... WebJan 10, 2024 · According to a study published in the journal Therapeutic Advances in Psychopharmacology, Wellbutrin usually begins to take effect within one to two weeks. However, the exact amount of time it takes to start working will vary from person to person, and some may experience relief from symptoms sooner than others.
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