WebCitation 6 SDE2 interacts with the C-terminus of TIM via its conserved SDE2 domain, and this interaction is necessary for stabilizing TIM against proteasome-dependent degradation. Intriguingly, unlike TIPIN that forms an obligate heterodimer with TIM, SDE2 regulates TIM specifically engaged at replication forks, implicating to the replisome-associated SDE2 … WebJan 4, 2024 · Sde2 facilitates spliceosomal association of Cactin/Cay1, with a functional link between Sde2 and Cactin further supported by genetic interactions and pre-mRNA splicing assays. These findings suggest that ubiquitin-like processing of Sde2 into a short-lived activated form may function as a checkpoint to ensure proper splicing of certain pre …
Hemanshu Sethi - SDE-2 - SIXT Research
WebSep 25, 2024 · Sde2 is translated as an inactive precursor protein, whose processing by two deubiquitinating enzymes (DUBs) serves as a checkpoint for its timely incorporation into … lightgbm early stopping
Splicing of branchpoint-distant exons is promoted by Cactin, Tls1 …
WebMar 3, 2024 · Possible Range. The estimated total pay for a SDE2 at Microsoft is $179,494 per year. This number represents the median, which is the midpoint of the ranges from our proprietary Total Pay Estimate model and based on salaries collected from our users. The estimated base pay is $132,490 per year. The estimated additional pay is $47,003 per year. WebMar 18, 2011 · Research highlights Sde2 is essential for telomere silencing. Sde2 is involved in the maintenance of genomic stability. Sde2 promotes the recruitment of SHREC, ... WebAug 7, 2024 · SDE2 depletion leads to widespread changes in alternative splicing, defects in ribosome biogenesis and ultimately complete loss of cell viability. Our data highlight SDE2 as a previously uncharacterized essential gene required for the assembly and maturation of the complexes that carry out two of the most fundamental processes in mammalian cells. peach ruffled shower curtain